Amyloid Prediction Index (API)

This application was developed by the KBASE research group to calculate the Amyloid Prediction Index (API), which predicts the risk for in vivo cerebral amyloid deposition in cognitively impaired patients (amnestic type mild cognitive impairment or Alzheimer’s disease dementia) with information that are routinely gathered in memory clinic practice.

The information used for the API include age, sex, duration of formal education attainment, history of hypertension, apolipoprotein E (APOE) genotype, and the raw score of word list recall test in the CERAD neuropsychological battery – all of which can be easily obtained in a memory clinic setting.

The algorithm of the API is published in Frontiers Aging Neuroscience (Lee et al., 2018, 10:309, doi: and is protected under patent law of Republic of Korea (Patent No. 10-2017-0162235). Only non-commercial utilization of this application by clinicians is permitted by the patent owners.

The development of this application was supported by a grant from the Ministry of Science and ICT, Republic of Korea (Grant No. NRF-2014M3C7A1046042).
 Age must be between 55 to 90 years.
 Please specify sex.
 Years of education must be between 0 to 24 years.
 Please specify history of hypertension.
 Word list recall test score must be between 0 to 10.
 Please specify APOE genotype.

API = 0%


Please note that the result of the API is not the absolute prediction for cerebral amyloid status. The result of the API is only meant to provide information for clinicians to determine whether there is indeed a need for further evaluation using amyloid PET scans. The KBASE research group and the authors of the API are not legally responsible or liable for any clinical outcome associated with its use. User discretion is advised.

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