Neuroimaging

All KBASE Participants underwent two-sessions of PET-MR scanning to obtain multi-modal imaging including [11C]PiB-PET, [18F]FDG-PET, MRI, and MRA using a 3.0T Biograph mMR (PET-MR) scanner.
The KBASE study is first large cohort study using simultaneous PET-MR. With the machine,a participant’s MR and PET images were obtained simultaneously in the same position. This is another distinct characteristic of the KBASE. Using PET-MR, we could reduce scanning time and exposure to radiation and much improve convenience for the participants. This also improved registration of PET images to MRI for image analyses.

Simultaneous acquisition based on PET-MR scanner

PET-MR
Amyloid PET Amyloid PET
([11C]PiB-PET)
low_arrow Structural MRI Structural MRI
(3D T1)

PET-MR fusion image PET-MR fusion image

PET imaging

Amyloid imaging: [11C]-PiB-PET

Tau PET imaging: [18F]AV-1451 PET

[18F]-FDG-PET

MRI and MRA

Structural MRI3D T1, T2, fluid-attenuated inversion recovery (FLAIR), diffusion tensor imaging (DTI), and susceptibility weighted imaging (SWI) sequences

Functional MRIResting-state fMRI and arterial spin labeling (ASL)

MR angiography